Risk factors for amyotrophic lateral sclerosis
نویسندگان
چکیده
منابع مشابه
Genetic Risk Factors for Amyotrophic Lateral Sclerosis
We performed a genome-wide association study in sporadic ALS (2,323 patients and 9,013 controls) and evaluated all SNPs with P < 1.0 x 10-4 in a second, independent cohort of 2,532 patients and 5,940 controls. Analysis of the genome-wide data revealed genome-wide signifi cance for one SNP, rs12608932 with P = 1.30 x 10-9. This SNP demonstrated robust replication in the second cohort (P = 1.86 x...
متن کاملRisk factors for amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis (ALS) is the most common motor neuron disease. It is typically fatal within 2-5 years of symptom onset. The incidence of ALS is largely uniform across most parts of the world, but an increasing ALS incidence during the last decades has been suggested. Although recent genetic studies have substantially improved our understanding of the causes of ALS, especially fami...
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The cause of motor neuron death in amyotrophic lateral sclerosis (ALS) remains a mystery. Initial implications of neurotrophic factor impairment involved in disease progression causing selective motor neuron death were brought forward in the late 1980s. These implications were based on several in vitro studies of motor neuron cultures in which a near to complete rescue of axotomized neonatal mo...
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متن کاملNeurotrophic factors and amyotrophic lateral sclerosis.
The cause of motor neuron death in amyotrophic lateral sclerosis (ALS) remains a mystery. Initial implications of neurotrophic factor impairment involved in disease progression causing selective motor neuron death were brought forward in the late 1980s. These implications were based on several in vitro studies of motor neuron cultures in which a near to complete rescue of axotomized neonatal mo...
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ژورنال
عنوان ژورنال: Clinical Epidemiology
سال: 2015
ISSN: 1179-1349
DOI: 10.2147/clep.s37505